10-硝基乳清酸

10-Nitrooleate is an endogenous, lipid-derived signaling molecule which functions as a potent ligand for PPARγ. It is known that this ligand activates the PPARγ receptor 7-fold at concentrations of 1 μM. Studies demonstrate that 10-nitrooleate is found in human plasma in the free acid form and can be esterified in phospholipids. In addition, 10-nitrooleate can release nitric oxide (NO) via decomposition or metabolism. Furthermore, 10-nitrooleate can effectively promote differentiation of preadipocytes at higher concentrations.

An endogenous lipid-derived signaling molecule

Store at -20° C

Liquid

78° C

n²⁰_D 1.48 (Predicted)

PPARγ: IC₅₀ = 1.61 µM (human); PPARα: IC₅₀ >15 µM (human)

pK_a: 4.77 (Predicted)

Soluble in ethanol, DMF (~1 mg/ml), and DMSO (~1 mg/ml).