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  • (±)10(11)-EpDPA
  • (±)10,11-EDP;(±)10,11-EpDPE;(±)10,11-epoxy DPA;(±)10,11-epoxy Docosapentaenoic Acid;
  • 货号: abs47046198
    CAS号: 895127-65-8
    分子式: C22H32O3
    分子量: 344.5
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    货号-规格 货期 价格 数量
    abs47046198-100ug 4周 ¥3666.00
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    产品描述
    描述
    Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA is a docosahexaenoic acid (DHA; Item No. 90310) epoxygenase metabolite, derived via epoxidation of the 10,11-double bond of DHA. It has been detected in rat brain and spinal cord, as well as human serum, and acts as a substrate for soluble epoxide hydrolase with a Km value of 5.1 µM.1,2 (±)10(11)-EpDPA and other epoxy metabolites of DHA are reported to demonstrate antihyperalgesic activity in inflammatory and neuropathic pain models and to potently inhibit angiogenesis and tumor growth in in vitro assays.1,3
    纯度
    ≥95%
    储存/保存方法
    Store at -20℃
    基本信息
    别名
    (±)10,11-EDP;(±)10,11-EpDPE;(±)10,11-epoxy DPA;(±)10,11-epoxy Docosapentaenoic Acid;
    参考文献
    参考文献
    1.Morisseau, C.,Inceoglu, B.,Schmelzer, K., et al. Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids. Journal of Lipid Research 51, 3481-3490 (2010).

    2.Lundström, S.L.,Yang, J.,Brannan, J.D., et al. Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids. Mol.Nutr.Food Res. 57(8), 1378-1389 (2013).

    3.Zhang, G.,Panigrahy, D.,Mahakian, L.M., et al. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc. Natl. Acad. Sci. USA 110(16), 6530-6535 (2013).

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