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  • 10-DEBC hydrochloride
  • 10-DEBC HCl;Akt Inhibitor X
  • 货号: abs819449
    CAS号: 925681-41-0
    分子式: C20H25ClN2O•HCl
    分子量: 381.34
    产品说明书
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    货号-规格 货期 价格 数量
    abs819449-5mg 4周 ¥2707.00
    - +
    abs819449-10mg 4周 ¥5174.00
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    大包装询价
    产品描述
    描述

    10-DEBC hydrochloride is a selective inhibitor of Akt (or termed PKB) , with an IC50 value of approximate 48 μM .

    纯度
    ≥95%
    储存/保存方法
    Store at -20° C
    形态
    Solid
    基本信息
    别名
    10-DEBC HCl;Akt Inhibitor X
    外观
    white powder
    IC50
    growth of Rh cell lines: IC50 = 2-5 µM; Akt: IC50 = <5 µM
    可溶性/溶解性
    Soluble in water (100 mM), and DMSO (100 mM).
    PubChem CID
    16760284
    生物活性
    In vitro(体外研究)
    As demonstrated by LDH and MTT tests, 10-DEBC dihydrochloride at 10 μM did not affect cell viability when it was applied alone. 10-DEBC dihydrochloride at this concentration in cisplatin-treated U251 cells abrogated the cytoprotective effect of metformin. 10-DEBC dihydrochloride showed neutralization effect on the antiapoptotic activity of metformin, increasing the cell membrane phosphatidylserine exposure and DNA fragmentation to the levels observed with cisplatin alone. In U251 cells, 10-DEBC dihydrochloride significantly induced the production of reactive oxygen species. In cisplatin-treated cells, 10-DEBC dihydrochloride consequently reduced the antioxidative effect of metformin.
    In vivo(体内研究)
    Studies in effects of 10-DEBC hydrochloride on BAT explants incubated with phentolamine were carried out. Without any effect on total Akt protein, 10-DEBC hydrochloride inhibited the phosphorylation of Akt Ser473 by ~40%. In WT explants, the 10-DEBC hydrochloride alone had no effect on the phosphorylation of Ser485/491 of AMPK, and did not affect the phentolamine effect. However, in β-AR KO explants, 10-DEBC hydrochloride blunted the AMPK Ser485/491 phosphorylation increased by phentolamine.
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