Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 µM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kin

A selective inhibitor of Akt/PKB

≥99 %

Desiccate at 4° C

Solid

AKT specific inhibitor X; 10-[4'-(N,N-Diethylamino)butyl]-2-ch​lorophenoxazine hydrochloride

170° C

n²⁰_D 1.57 (Predicted)

Akt: IC₅₀ < 5 µM; growth of Rh cell lines: IC₅₀ = 2-5 µM

Soluble in water (1 mg/ml), DMSO (100 mM), and methanol.

MFCD09038570

16760284