1-Oleoyl lysophosphatidic acid sodium salt
- Lysophosphatidic acid；LPA
货号： abs819548
| 货号-规格 | 货期 | 价格 | 数量 |
| abs819548-5mg | 4周 | ￥1191.00 | - + |
| abs819548-10mg | 4周 | ￥2195.00 | - + |
大包装询价| 产品描述 | ||
| 描述 | 1-Oleoyl lysophosphatidic acid (LPA) is a naturally occurring phospholipid with various effects. LPA is widely distributed in many tissues. Similar to many other biomediators, LPA interacts with cells via specific cell surface receptors, such as G proteincoupled receptors, to induce biological effects. | |
| 纯度 | 98% | |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. | |
| 基本信息 | ||
| 别名 | Lysophosphatidic acid；LPA | |
| 外观 | Off-White Solid | |
| 可溶性/溶解性 | PBS | |
| 生物活性 | ||
| In vitro(体外研究) | LPA could mediate signal transduction via Edg/LPA receptor, inducing the proliferation, migration, adhesion and antiapoptotic function of tumor cells. Additionally, LPA was found to elicit upregulation of VEGF, leading to an indirect influence on initiation and progression of malignancies. LPA could also stimulate matrix metalloproteinase secretion and tumor angiogenesis factor . | |
| In vivo(体内研究) | LPA was tested for its vascular remodeling effect in a rat model of hypoxic pulmonary hypertension. Serum from animals in the hypoxic group showed higher chemoattractant properties toward rat primary lung fibroblasts, and such cell migration increase was prevented by the LPA receptor 1 and 3 antagonists. LPA also found to increase adhesive properties of human pulmonary artery endothelial cells, via the activation of LPA receptor 1 or 3. | |
| 温馨提示：本产品仅作科研实验使用，不支持临床等研究 |
- 实验方法 实验条件
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