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Gaboxadol (hydrochloride)

THIP;

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货号 abs47046136
规格 价格
¥1171
库存状态:4周

数量:

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概述
描述 Gaboxadol is a GABAA receptor agonist whose potency varies depending on the receptor subunit composition (partial agonist at α1β2γ2 (ED50 = 143 µM), full agonist at α5 (ED50 = 28-129 µM), and super agonist at α4β3δ (ED50 = 6 µM)).1 It also acts as an antagonist at ρ1 GABAC receptors (IC50 = 25 µM).1 Gaboxadol has been studied as a non-opioid analgesic and a novel hypnotic agent.2,3,4
别名 THIP;
性能
保存方法 Store at -20℃
纯度 ≥98%
分子量 176.6
分子结构式
化学式 C6H8N2O2 • HCl
CAS号 85118-33-8
参考文献
1.Johnston, G.A.R.,Chebib, M.,Hanrahan, J.R., et al. Neurochemicals for the investigation of GABAC receptors. Neurochemical Research 35(12), 1970-1977 (2010).

2.Drasbek, K.R. and Jensen, K. THIP, a hypnotic and antinociceptive drug, enhances an extrasynaptic GABAA receptor-mediated conductance in mouse neocortex. Cerebral Cortex 16(8), 1134-1141 (2006).

3.Vashchinkina, E.,Panhelainen, A.,Vekovischeva, O.Y., et al. GABA site agonist gaboxadol induces addiction-predicting persistent changes in ventral tegmental area dopamine neurons but is not rewarding in mice or baboons. Journal of Neuroscience 32(15), 5310-5320 (2012).

4.Deacon, S.,Staner, L.,Staner, C., et al. Effect of short-term treatment with gaboxadol on sleep maintenance and initiation in patients with primary insomnia. Sleep 30(3), 281-287 (2007).