|描述||Amphomycin is a natural antibacterial lipopeptide first isolated from S. canus. Lipopeptides are cyclic depsipeptides with a peptidyl side chain capped with a saturated alkyl tail.1 They preferentially target Gram-positive bacteria and may be useful against drug resistant strains.1 Amphomycin is also an inhibitor of peptidoglycan synthesis in both bacterial and mammalian systems, as it binds with phosphorylated substrates in a calcium-dependent manner.2,3,4,5|
|保存方法||Store at -20℃|
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3.Kang, M.S.,Spencer, J.P. and Elbein, A.D. Amphomycin inhibition of mannose and GlcNAc incorporation into lipid-linked saccharides. The Journal of Biological Chemisty 253(24), 8860-8866 (1978).
4.Banerjee, D.K. Amphomycin inhibits mannosylphosphoryldolichol synthesis by forming a complex with dolichylmonophosphate. The Journal of Biological Chemisty 264(4), 2024-2028 (1989).
5.Cooper, H.N.,Gurcha, S.S.,Nigou, J., et al. Characterization of mycobacterial protein glycosyltransferase activity using synthetic peptide acceptors in a cell-free assay. Glycobiology 12(7), 427-434 (2002).