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Amphomycin

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货号 abs47045068
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¥6930
库存状态:4周

数量:

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概述
描述 Amphomycin is a natural antibacterial lipopeptide first isolated from S. canus. Lipopeptides are cyclic depsipeptides with a peptidyl side chain capped with a saturated alkyl tail.1 They preferentially target Gram-positive bacteria and may be useful against drug resistant strains.1 Amphomycin is also an inhibitor of peptidoglycan synthesis in both bacterial and mammalian systems, as it binds with phosphorylated substrates in a calcium-dependent manner.2,3,4,5
性能
保存方法 Store at -20℃
纯度 ≥95%
分子量 1290.4
分子结构式
化学式 C58H91N13O20
CAS号 1402-82-0
参考文献
1.Fair, R.J. and Tor, Y. Antibiotics and bacterial resistance in the 21st century. Perspectives in Medicinal Chemistry 6, 25-64 (2014).

2.Spencer, J.P. and Elbein, A.D. Transfer of mannose from GDP-mannose to lipid-linked oligosaccharide by soluble mannosyl transferase. Proceedings of the National Academy of Sciences of the United States of America 77(5), 2524-2527 (1980).

3.Kang, M.S.,Spencer, J.P. and Elbein, A.D. Amphomycin inhibition of mannose and GlcNAc incorporation into lipid-linked saccharides. The Journal of Biological Chemisty 253(24), 8860-8866 (1978).

4.Banerjee, D.K. Amphomycin inhibits mannosylphosphoryldolichol synthesis by forming a complex with dolichylmonophosphate. The Journal of Biological Chemisty 264(4), 2024-2028 (1989).

5.Cooper, H.N.,Gurcha, S.S.,Nigou, J., et al. Characterization of mycobacterial protein glycosyltransferase activity using synthetic peptide acceptors in a cell-free assay. Glycobiology 12(7), 427-434 (2002).