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Gilvocarcin V

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货号 abs42018992
规格 价格
¥1950
库存状态:4周
¥6600
库存状态:4周

数量:

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概述
描述 Gilvocarcin V is the major analogue of a complex of C-glycoside antitumor actives isolated from a Streptomyces sp. Gilvocarcin V contains a vinyl group in the 8-position and is the most potent analogue of the complex. It is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. The metabolite displays potent antibacterial, antifungal, antiviral and antitumor activity. Recent research on the gilvocarcins suggests that they act as photoactivated crosslinkers of DNA to histones. Gilvocarcin V has also been shown to be cytotoxic against Gram-positive bacteria. Mediates a unique cross-linking reaction between DNA and histidine H3. And is shown to be weakly active against Gram-negative bacteria, fungi and tumors. Also an antineoplastic and a photosensitizing compound.
应用 A metabolite that displays potent antibacterial, antifungal and antiviral activity
性能
外观 Crystalline
密度 1.45 g/cm3 (Predicted)
熔点 322.54° C (Predicted)
沸点 821.61° C at 760 mmHg (Predicted)
保存方法 Store at -20° C
纯度 >95%
分子量 494.5
化学式 C27H26O9
溶解性 Soluble in DMSO, DMF (moderately), methanol (moderately), ethanol (moderately), and water (poor).
CAS号 77879-90-4
折射率 n20D 1.70 (Predicted)
SMILES CC(C1C(C(C(O1)C2=C3C(=C(C=C2)O)C(=CC4=C3OC(=O)C5=CC(=CC(=C54)OC)C=C)OC)O)O)O
来源 Streptomyces sp.