May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription.
Nucleus speckle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with NEK6 in the centrosome
CIR Antibody (N-term) (Cat. #abs102190) western blot analysis in THP-1 cell line,human placenta,rat heart and skeletal muscle lysates (35ug/lane).This demonstrates the CIR antibody detected the CIR protein (arrow).