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Recombinant Mouse Insulin-like Growth Factor-Binding Protein 5/IGFBP5 (C-6His)

BP-5; IGFBP-5; IGF-binding protein 5; Insulin-like growth factor-binding protein 5;

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货号 abs04621
规格 价格
¥ 840
库存状态:1-2周
¥ 2520
库存状态:1-2周
¥ 12320
库存状态:1-2周
¥ 17600
库存状态:1-2周

数量:

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概述
描述 Recombinant Mouse Insulin-like growth factor-binding protein 5 is produced by our expression system and the target gene encoding Leu20-Glu271 is expressed
别名 BP-5; IGFBP-5; IGF-binding protein 5; Insulin-like growth factor-binding protein 5;
形态 Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
来源 Human Cells
氨基酸序列 LGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQD EEKPLHALLHGRGVCLNEKSYGEQTKIERDSREHEEPTTSEMAEETYSPKVFRPKHTRISELKAE AVKKDRRKKLTQSKFVGGAENTAHPRVIPAPEMRQESEQGPCRRHMEASLQEFKASPRMVPRAVY LPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHAFDSSNVEHHHHHH
内毒素水平 Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.
Accession # Q07079
背景 Mouse Insulin-like growth factor-binding protein 5(IGFBP-5) belongs to the superfamily of insulin-like growth factor (IGF) binding proteins. It contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. Mouse IGFBP-5 shows 97% aa sequence identity with those of human and rat IGFBP-5. It is expressed mostly in kidney, uterus and gastrocnemius muscle. It also expressed by fibroblasts, myoblasts and osteoblasts, making it the predominant IGFBP found in bone extracts. IGFBP-5 has a strong affinity for hydroxyapatite, allowing it to bind to bone cells. When bound to extracelluar matrix, IGFBP-5 is protected from proteolysis and potentiates IGF activity, but when it is soluble, IGFBP-5 is cleaved to a biologically inactive 21 kDa fragment. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
性能
纯度 Greater than 95% as determined by reducing SDS-PAGE.