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Recombinant Mouse IL-23 Receptor/IL-23R (C-Fc)

Interleukin-23 receptor, Il23r, IL-23 receptor, IL-23R, interleukin 23 receptor

收藏商品 产品说明书
货号 abs04492
规格 价格
¥ 760
库存状态:1-2周
¥ 2000
库存状态:1-2周
¥ 12320
库存状态:1-2周
¥ 17600
库存状态:1-2周

数量:

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概述
描述 Recombinant Mouse Interleukin-23 Receptor is produced by our Mammalian expression system and the target gene encoding Gly24-Asp372 is expressed with a Fc tag at the C-terminus.
别名 Interleukin-23 receptor, Il23r, IL-23 receptor, IL-23R, interleukin 23 receptor
形态 Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
来源 Human Cells
氨基酸序列 GITSINCSGDMWVEPGEIFQMGMNVSIYCQEALKHCRPRNLYFYKNGFKEEFDITRINRTTARIW YKGFSEPHAYMHCTAECPGHFQETLICGKDISSGHPPDAPSNLTCVIYEYSGNMTCTWNTGKPTY IDTKYIVHVKSLETEEEQQYLASSYVKISTDSLQGSRKYLVWVQAVNSLGMENSQQLHVHLDDIV IPSASIISRAETTNDTVPKTIVYWKSKTMIEKVFCEMRYKTTTNQTWSVKEFDANFTYVQQSEFY LEPDSKYVFQVRCQETGKRNWQPWSSPFVHQTSQETGKRNWQPWSSPFVHQTSQTVSQVTAKSSH EPQKMEMLSATIFRGHPASGNHQDVDDIEGRMDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKP KDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQD WLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDI AVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGK
内毒素水平 Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.
Accession # Q8K4B4
背景 Interleukin 23 receptor (IL23R), a heterodimer of the IL12 receptor β1 (IL12Rβ1) and IL12Rβ2, is a type I cytokine receptor for IL23. IL23R is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis, multiple sclerosis, Graves's ophtalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.
性能
纯度 Greater than 95% as determined by reducing SDS-PAGE.