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您现在的位置: 首页 > 常规试剂 > 重组蛋白 > 其他重组蛋白 > Recombinant Mouse Lymphocyte Activation Gene 3/LAG-3/CD223 (C-6His)

Recombinant Mouse Lymphocyte Activation Gene 3/LAG-3/CD223 (C-6His)

Lymphocyte activation gene 3 protein,CD223,Lag3, REF: C1128

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货号 abs04480
规格 价格
¥ 1200
库存状态:1-2周
¥ 3520
库存状态:1-2周
¥ 12320
库存状态:1-2周
¥ 17600
库存状态:1-2周

数量:

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概述
描述 Recombinant Mouse LAG-3 is produced by our Mammalian expression system and the target gene encoding Ser23-Leu442 is expressed with a 6His tag at the C-terminus.
别名 Lymphocyte activation gene 3 protein,CD223,Lag3, REF: C1128
形态 Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
来源 Human Cells
氨基酸序列 SGPGKELPVVWAQEGAPVHLPCSLKSPNLDPNFLRRGGVIWQHQPDSGQPTPIPALDLHQGMPSP RQPAPGRYTVLSVAPGGLRSGRQPLHPHVQLEERGLQRGDFSLWLRPALRTDAGEYHATVRLPNR ALSCSLRLRVGQASMIASPSGVLKLSDWVLLNCSFSRPDRPVSVHWFQGQNRVPVYNSPRHFLAE TFLLLPQVSPLDSGTWGCVLTYRDGFNVSITYNLKVLGLEPVAPLTVYAAEGSRVELPCHLPPGV GTPSLLIAKWTPPGGGPELPVAGKSGNFTLHLEAVGLAQAGTYTCSIHLQGQQLNATVTLAVITV TPKSFGLPGSRGKLLCEVTPASGKERFVWRPLNNLSRSCPGPVLEIQEARLLAERWQCQLYEGQR LLGATVYAAESSSGAHSARRISGDLKGGHLHHHHHH
内毒素水平 Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.
Accession # Q61790
背景 Lymphocyte-activation gene 3 (LAG3), also known as CD223, is a type I transmembrane protein with four extracellular Ig-like domains, designated D1 to D4 and belongs to the immunoglobulin superfamily. The gene for LAG3 lies adjacent to the gene for CD4 on human chromosome 12p13.32 and shares approximately 20% identical to the CD4 gene. LAG3 is expressed on activated T cells, natural killer cells, B cells and plasmacytoid dendritic cells. LAG3 binds with high affinity to MHC class II molecules, and it interferes competitively with the binding of CD4 to MHC class II and thereby blocks the transduction of stimulatory signals mediated by this interaction. LAG3 negatively regulates cellular proliferation, activation, and homeostasis of T cells, and plays an important role in Treg suppressive function. LAG3 is the target of various drug development programs to develop new treatments for cancer and autoimmune disorders. The soluble form, sLAG-3, is being developed as a cancer drug.
性能
纯度 Greater than 95% as determined by reducing SDS-PAGE.