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Recombinant Mouse Interferon γ Receptor 1/IFN-γ R1/CD119 (C-6His)

CD119, Interferon gamma receptor 1, IFNGR1, IFN-gamma receptor 1, IFN-gamma-R1, CD119 antigen, IFN gamma receptor 1, IFNGR, immune interferon receptor 1, interferon gamma receptor 1, interferon-gamma receptor alpha chain

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货号 abs04476
规格 价格
¥ 200
库存状态:1-2周
¥ 560
库存状态:1-2周
¥ 3600
库存状态:1-2周
¥ 4800
库存状态:1-2周

数量:

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概述
描述 Recombinant Mouse Interferon gamma Receptor 1 is produced by our Mammalian expression system and the target gene encoding Ala26-Asp253 is expressed with a 6His tag at the C-terminus.
别名 CD119, Interferon gamma receptor 1, IFNGR1, IFN-gamma receptor 1, IFN-gamma-R1, CD119 antigen, IFN gamma receptor 1, IFNGR, immune interferon receptor 1, interferon gamma receptor 1, interferon-gamma receptor alpha chain
形态 Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
来源 Human Cells
氨基酸序列 ALTSTEDPEPPSVPVPTNVLIKSYNLNPVVCWEYQNMSQTPIFTVQVKVYSGSWTDSCTNISDHC CNIYEQIMYPDVSAWARVKAKVGQKESDYARSKEFLMCLKGKVGPPGLEIRRKKEEQLSVLVFHP EVVVNGESQGTMFGDGSTCYTFDYTVYVEHNRSGEILHTKHTVEKEECNETLCELNISVSTLDSR YCISVDGISSFWQVRTEKSKDVCIPPFHDDRKDVDHHHHHH
内毒素水平 Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.
Accession # P15261
背景 The tetrameric receptor complex for IFNγ consists of two subunits, IFNGR1 (IFNγ Rα) and IFNGR2 (IFNγ Rβ), through which the dimeric IFN-γ exerts its biological functions, including antiviral, antiproliferation and immune-modulatory activity in mammals. Both IFNGR1 and IFNGR2 are single transmembrane proteins belonging to the class II cytokine family. FNGR1, widely expressed in most host cells, is essential for IFNγ binding, receptor trafficking, and signal transduction. IFNGR1 possesses an intracellular Janus tyrosine kinase (JAK) 1 binding site, a signal transducer and activator of transcription 1 (STAT1) binding site. The resulting STAT1 homodimers translocate from the cytoplasm to the nucleus and bind to the interferon-gamma activated sequence (GAS) promoter to induce expression of downstream interferon stimulated genes (ISGs).
性能
纯度 Greater than 95% as determined by reducing SDS-PAGE.