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Recombinant Mouse Myostatin/MSTN/GDF-8 (C-6His)

Growth/differentiation factor 8,GDF-8,Myostatin,Mstn,Gdf8

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货号 abs04360
规格 价格
¥ 1200
库存状态:1-2周
¥ 3520
库存状态:1-2周
¥ 12320
库存状态:1-2周
¥ 19200
库存状态:1-2周

数量:

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概述
描述 Recombinant Mouse Growth Differentiation Factor 8 is produced by our Mammalian expression system and the target gene encoding Asn25-Ser265 is expressed with a 6His tag at the C-terminus.
别名 Growth/differentiation factor 8,GDF-8,Myostatin,Mstn,Gdf8
形态 Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
来源 Human Cells
氨基酸序列 NEGSEREENVEKEGLCNACAWRQNTRYSRIEAIKIQILSKLRLETAPNISKDAIRQLLPRAPPLR ELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQADGKPKCCFFKFSSKIQYNKVVK AQLWIYLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMSPGTGIWQSIDVKTVLQNWLKQ PESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSVDHHHHHH
内毒素水平 Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.
Accession # O08689
背景 Mouse Growth/differentiation factor 8(Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. It is expressed specifically in developing and adult skeletal muscle. It exists as a homodimer, and interacts with WFIKKN2, leading to inhibit its activity. This protein can act specifically as a negative regulator of skeletal muscle growth. It regulates cell growth and differentiation in both embryonic and adult tissues. Experiments in mice have improved that GDF-8 is a key regulator of mesenchymal stem cell proliferation and differentiation, and mice lacking Myostatin encoding gene show decreased body fat and a generalized increase in bone density and strength.
性能
纯度 Greater than 95% as determined by reducing SDS-PAGE.